A comparative study on the application of different endoscopic diagnostic methods in the differential diagnosis of benign and malignant bile duct strictures

Objective To compare the diagnostic value of cytobrush, ERCP-guided biopsy, SpyGlass direct visual impression and SpyGlass-guided biospy (SpyBite) in differential diagnosis benign malignant bile duct strictures. Methods The data 1,008 patients who were clinically diagnosed with indeterminate biliary strictures underwent or SpyBite at First Affiliated Hospital Nanchang University between January 2010 December 2019 collected analyzed retrospectively. final diagnose was determined by surgical pathological specimen follow-up (Malignant stricture can be identified if showed progression during one year follow-up). above endoscopic methods evaluated means sensitivity, specificity, accuracy, positive predictive value, negative etc. safety incidence rate adverse events. Results In terms standard biopsy group (48.6%) (61.5%) significantly higher than cytobrush (32.0%), (100%) any other group. As far as specificity concerned, (99.0%), (99.3%) (55.6%), but there no statistical difference among three groups above. accuracy (65.3%), (80.0%) (44.4%), (54.8%). safety, post-ERCP cholangitis. Conclusion combined better for sensitivity compared conventional such biopsy. Furthmore, rates events after examination similar to those except cholangitis, which could controlled antibiotics might avoided adequate drainage.